Serotonin is a key hormone in promoting feelings of happiness and well-being. It plays a role in regulating your digestion, sleep, bones, inflammation, libido, and memory. If you’re dealing with depression, anxiety, mood disorders, or insomnia, you may want to ask your doctor about a possible serotonin deficiency.
You can support your body's natural happiness hormone by understanding how serotonin works in the body. Discover how to increase serotonin naturally with simple lifestyle changes, and learn when your body might need support from supplements or medications.
Depression is a very real struggle, and support is easy to reach. If you've found this article because you are considering self-harm, call the National Suicide Prevention Lifeline at 1-800-273-8255 right now, or visit their website for free, 24/7 live chat support.
What Is Serotonin?
Serotonin (5-hydroxytryptamine) is a molecule that helps your nervous system communicate. You may know it as “the happy molecule” for its role in regulating happiness, anxiety, and mood. While most serotonin operates in the gut, scientists best understand the effects of serotonin in the brain, where it impacts our mood and sleep.
Is Serotonin a Hormone or a Neurotransmitter?
The short answer is, serotonin can work as a neurotransmitter or a hormone, depending on where you find it. Serotonin functions as a neurotransmitter in the central nervous system (your brain and spinal cord) and as a hormone in the peripheral nervous system (everywhere else).
What Does Serotonin Regulate?
Serotonin plays several roles throughout the body, many of which we're still working to understand. Did you know that 95% of your serotonin actually exists in your gut and not your brain? Still, we tend to associate serotonin with its effect on mood and happiness.
Research shows that high serotonin in the brain general means happier moods, while low serotonin may be linked to an increased risk for depression.
That said, it’s not entirely clear whether serotonin regulates our mood, or our mood affects our serotonin. Research shows that adequate serotonin in the brain is important in regulating our anxiety and fear responses.
Serotonin also supports healthy sleep. Our bodies use serotonin to produce melatonin, the hormone that regulates our inner clock and sleep cycles. Our digestive system also benefits from serotonin, as it plays a role in regulating sugar levels, reducing inflammation in the gut, and keeping food moving through your digestive tract.
Signs You Need To Increase Serotonin Levels
A serotonin deficiency can occur when serotonin production is too low, or when there's enough serotonin, but your brain isn't using it properly. This can happen when your brain has too few serotonin receptors or when serotonin is being stored or broken down too quickly.
You can read all about serotonin deficiency and its symptoms here.
Because we can't test directly for serotonin levels in the brain, your doctor may identify a serotonin deficiency through symptoms. The best-known signs of low serotonin include depression and anxiety, often accompanied by poor sleep. Less severe symptoms, such as general sadness (especially with a lack of sunshine), low self-esteem, brain fog, and anger can also point to low serotonin.
How To Increase Serotonin With Drugs
Many pharmaceutical treatments for depression and anxiety focus on boosting serotonin. SSRIs, or selective serotonin reuptake inhibitors, are a common group of prescription antidepressants. SSRIs don't actually increase serotonin, but they do help your brain get the most mileage out of the serotonin already present.
How do SSRIs work?
Serotonin acts like a messenger in our brains' synapses (the space between neurons). As long as serotonin is present in the synapse, it can continue sending messages. Eventually, active serotonin molecules get reabsorbed by a neuron. SSRIs can reduce symptoms of depression by preventing this reabsorption, allowing the serotonin to stay in the active synapse area.
This means that even with low serotonin, your brain neurons can still receive the messages they need to fuel a positive mood. A similar family of drugs, SNRIs (serotonin and norepinephrine reuptake inhibitors), reduce the reabsorption of both serotonin and norepinephrine.
Common SSRIs include Prozac®, Celexa®, and Zoloft®.
Common SNRIs include Pristiq®, Cymbalta®, Savella®, Effexor®.
While SSRIs can be hugely beneficial in some cases, they have a downside: the long-term use of SSRIs can make serotonin deficiencies even worse. Additionally, while SSRIs can reduce depression symptoms by increasing serotonin availability, they don't address the root cause of low serotonin levels.
If you are on an SSRI or SNRI and wish to stop, you must absolutely bring this up with your prescribing doctor and adhere to their guidance on dosage. The side effects of stopping SSRIs abruptly can be brutal and dangerous, and this isn't something you can always power through. You can avoid a lot of suffering and side effects if your doctor is keeping a close eye on your dosage adjustments and symptoms.
How To Increase Serotonin Naturally
Everyone is different. For some people, an exercise session and some time outside will create an immediate sense of relief. For others, these strategies may address symptoms gradually over time. Some cases are severe and require medical intervention. As always, it's best to involve your doctor in any concerning health matter.
Here are some things to try that could increase serotonin naturally, with simple lifestyle changes that may support your serotonin production.
Soak up some sun
Sunshine makes you happy, and science agrees: Exposure to sunlight helps increase serotonin production. This can help explain the seasonal depression that affects so many people in the darker winter months and shine some light on the benefits of getting outside.
Several studies show that exercise may increase serotonin and tryptophan (the building block of serotonin) levels in the brain. More research links exercise to improved mood, making it a potentially low-risk, low-cost treatment for depression.
Here's good news: among the many benefits of massage, research shows an increase in serotonin and decreased cortisol (the stress hormone) following massage. In this study on depression in pregnant women, mothers who received regular massages from their partners reported happier moods, lower anxiety, and healthier outcomes for their babies.
“Want to be happier? Stress less!” I know, I know, this sounds almost offensively unhelpful. Before you roll your eyes, let's glance at the facts: Excess stress causes your body to produce cortisol, and rising cortisol levels deplete serotonin. Finding simple ways to reduce your daily stress, such as meditation, taking a walk, or dancing to your favorite song, can help save your serotonin.
Reduce alcohol intake
While there's nothing wrong with an occasional toast, alcohol can wreak havoc on our hormones. Alcohol has depressant effects of its own, and excess consumption can reduce the serotonin levels in your brain.
Plus, alcohol isn’t great for hormones overall. You can read about how alcohol can affect your hormones and periods here.
Foods that increase serotonin
How many of us reach for the snacks when we feel blue? 🙋🏻♀️ It turns out that the sugary or high-carb snacks we use as comfort foods actually give us a quick hit of serotonin. But as you might guess, this isn't the way to go. Sugar and refined carbohydrates can also spike cortisol and contribute to inflammation, two factors that will crash your mood just as quickly.
You can read more about the Anxiety-Sugar Connection here.
Instead of reaching for sweets, try adding these serotonin-boosters to your diet.
The beneficial omega-3 fatty acids found in cold-water fatty fish play a role in serotonin's function in the brain. Research specifically shows that EPA and DHA from fish oil appear to regulate both the release of serotonin and serotonin receptors' function. Low levels of essential omega-3 fatty acids may impair the serotonin receptor and result in lower levels of serotonin.
Click here to learn more about the benefit of omega-3 fatty acids.
Green Tea and Turmeric
Research shows that theanine, an active compound in green tea, and curcumin from turmeric, can both raise brain serotonin levels. Even more, these ingredients also reduce inflammation, making them beneficial additions to your pantry.
Learn more about the benefits of turmeric here.
Tryptophan Supplements for Serotonin
Tryptophan is the amino acid our bodies use to create serotonin. It's also a unique example of a time when a supplement might be more beneficial than a whole food. Here's why: tryptophan is the building block for serotonin, but this essential amino acid is found in protein-rich foods such as milk, nuts, meats and cheeses. It turns out, a high protein meal actually decreases the amount of tryptophan that can enter the brain (and thus the serotonin the brain can produce).
The workaround? Tryptophan supplements allow you to get tryptophan without having to consume protein alongside it. Research shows that tryptophan supplements, especially when used with other treatments, may be useful in boosting serotonin and reducing depression symptoms.
Especially in latitudes with less sunlight, vitamin D deficiency is very common. Vitamin D, which our bodies produce in response to sunlight, is a necessary factor in the brain’s production of serotonin. Your doctor can help you evaluate your vitamin D levels with a blood test, in order to understand if supplementation can benefit you.
You can learn more about the benefits of vitamin D here.
5-HTP Supplements for Serotonin:
Despite its common use, I do not recommend 5-HTP as a serotonin-boosting supplement to treat clinical depression without the supervision of your provider. 5-HTP is the precursor to serotonin, which your body also converts into melatonin, a molecule that aids in sleep. Unlike serotonin, 5-HTP is small enough to cross the blood brain barrier.
These factors make it sound like an enticing supplement for those with both depression, but high dose 5-HTP has some serious side effects.
With long-term use (consistently taking for years), as it actually depletes dopamine and norepinephrine, two other neurotransmitters critical to mood regulation. Even with sufficient serotonin, a deficiency in these neurotransmitters can also lead to depression.
Further, researchers linked long-term 5-HTP use with pre-existing heart valve disease in rats. That may or may not hold true for humans – further research is needed.
And if you're on SSRIs, 5-HTP is a big no-no. Supplementing 5-HTP should never happen together with SSRIs or other antidepressants, a combination that can lead to dangerously high levels of serotonin, known as serotonin syndrome.
If you suspect a serotonin deficiency is affecting your mood, start by talking to your doctor. These articles can serve as a guide to help your conversation and make sure you have the information you need.
Serotonin Deficiency, What’s the Risk?
KEEPING IT REAL, WHILE KEEPING YOU EDUCATED
Featuring a 28 day plan to take back your cycle and dozens of charts, checklists, and diagrams to help along the way.
- Serotonin. Science Direct. 2015.
- Shajib MS, Khan WI. The role of serotonin and its receptors in activation of immune responses and inflammation. Acta Physiol (Oxf). 2015. 213. 561-574.
- Banskota S, Ghia JE, Khan WI. Serotonin in the gut: Blessing or a curse. Biochimie. 2019. 161. 56-64.
- Loonen AJ, Ivanova SA. Circuits Regulating Pleasure and Happiness-Mechanisms of Depression. Front Hum Neurosci. 2016. 10. 571.
- Waider J, Popp S, Milnar B, et. al. Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity. Front Neurosci. 2019.
- Whitney MS, Shemery AM, Yaw AM. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. J. Neurosci. 2016. 36. 9828-9842.
- Jones LA, Sun EW, Martin AM, Keating DJ. The ever-changing roles of serotonin. Int J Biochem Cell Biol. 2020. 125.
- Siesser WB, Sachs BD, Ramsey AJ, et al. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS Chem Neurosci. 2013. 4. 84-88.
- Sansone RA, Sansone LA. Sunshine, serotonin, and skin: a partial explanation for seasonal patterns in psychopathology?. Innov Clin Neurosci. 2013. 10. 20-24.
- Young SN. How to increase serotonin in the human brain without drugs. J. Psychiatry Neurosci. 2007. 32. 394-399.
- Field T. Massage therapy research review. Complement Ther Clin Pract. 2014. 20. 224-229.
- Field T, Diego MA, Hernandez-Reif M, Schanberg S, Kuhn C. Massage therapy effects on depressed pregnant women. J Psychosom Obstet Gynaecol. 2004. 25. 115-122.
- Tafet GE, Idoyaga-Vargas VP, Abulafia DP, et al. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 2001. 1. 388-393.
- Badawy AA. Alcohol and violence and the possible role of serotonin. Crim Behav Ment Health. 2003. 13. 31-44.
- Wurtman J, Wurtman R. The Trajectory from Mood to Obesity. Curr Obes Rep. 2018. 7. 1-5.
- Patrick RP, Ames BN. Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. The FASEB Journal. 2015.
- Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006. 6. 21-30.
- Kulkarni, S.K., Bhutani, M.K. & Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology. 2008.
- Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 2016. 8. 56.
- Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014. 28. 2398-2413.
- Gendle MH, Young EL, Romano AC. Effects of oral 5-hydroxytryptophan on a standardized planning task: insight into possible dopamine/serotonin interactions in the forebrain. Hum Psychopharmacol. 2013. 28. 270-273.
- Patel YA, Marzella N. Dietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment Syndrome. Am J Case Rep. 2017. 18. 926-930.