Mirena Side Effects: Mood and Other IUD Concerns

Dr. Jolene BrightenPublished: Last Reviewed: Thyroid & Hormone Balance Leave a Comment

Mirena side effects can seriously disrupt your mood, your hormones, and your life. But all women don't have the same experience, in fact, some find this is the most reliable method with the least amount of side effects. Others are left asking, “Is Mirena messing with my hormones”?

In this article I am going to share with you what you should know before you place that IUD and what you should look out for if you already have a hormonal IUD. We're going to review the benefits and risks associated with hormonal IUDs, which is what we need to consider before starting any medical intervention.

Benefits of Mirena

While there are some serious side effects and complications associated with hormonal IUDs, there are also a few benefits worth noting. Before we dive into Mirena side effects to be in the know on, here are some of the reasons why women choose this IUD in the first place.

1. Daily Convenience

There is no pill to take, patch to place, or ring to insert. The Mirena can be placed and left for up to five years.

2. Highly Effective

The Mirena coil, like other IUDs, is more effective at preventing pregnancy than other common forms of birth control, like the pill or condoms.

How Does the Mirena Work?

The Mirena IUD, like all hormonal IUDs, contains a synthetic hormone called Levonorgestrel, a progestin, that it slowly releases in your body over time. While progestin sounds like progesterone, it is not, nor does it behave like progesterone in your body.

Instead, the progestin released thins the lining of your uterus, the endometrium, so a fertilized egg would be unable to implant. This is one way in which women have lighter or absent periods while using a hormonal IUD.

It is also designed to stop ovulation by suppressing the production of two brain hormones—Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). FSH and LH work together to mature an egg and trigger ovulation. They are also responsible for signaling the rise and fall of your hormones. It also thickens cervical secretions, making it difficult for sperm to make it to the egg in the event ovulation does occur.

Progestin Containing IUDs

The Mirena isn’t the only progestin containing IUD, but it does have the highest amount of hormones. Here is the list of hormonal IUDs commonly available in the United States.


The Mirena contains 52 mg of progestin and is estimated to release 20 micrograms daily. After 5 years the device will need to be removed.


This IUD contains the same amount of progestin (52 mg), but is estimated to release 18.6 micrograms of progestin daily, which is slightly lower than the Mirena. Liletta needs to be removed 4 years after having it placed.


Kyleena contains 19.5 mg progestin and is supposed to release 17.5 micrograms daily. Like the Mirena, this is approved for 5 years of use.


Skyla IUD has the lowest amount of total progestin (13.5 mg) and released progestin at 14 micrograms daily. It is only approved for 3 years of use.

Side Effects of Mirena

Perforation and expulsion are two of the scarier side effects associated with the Mirena and other IUDs. Perforation is when the IUD embeds in your uterus  and expulsion is when the uterus pushes the IUD out. While scary, they are not very common. But you should still be aware this Mirena coil side effect can happen and what to look for.

IUD Perforation

An IUD perforation occurs when the device either attaches to the uterus or punctures through. This can lead to scarring, damaged organs, infection, infertility and surgery.

Perforation more often occurs when the IUD is placed, rather than it migrating later. The solution? Get your IUD placed by a pro!

IUD Perforation Symptoms

  • Severe pelvic or abdominal pain that does not go away
  • Bleeding
  • Pain with intercourse
  • Absent strings or shorter

What’s the risk of perforation?

The risk of perforation is low at about 1 in every 1,000 IUDs that are placed. Having an IUD placed by an experienced practitioner may lower this risk. If you’re feeling really concerned, talk to your doctor about the position of your uterus and any other individualized risk factors that could contribute.

Bleeding and pain come with the territory when you place an IUD in your uterus, but excessive pain, increased bleeding or not being able to feel the strings is a sign that a perforation may have occurred.

When it comes to IUD side effects, if you suspect anything is wrong, get to your doctor immediately. A quick ultrasound can help them see what is going on and at the least, give you peace of mind that everything is ok.

Expulsion—Your Uterus Kicks It OUT

Expulsion occurs after an IUD is placed and is your uterus pushing the device out. Hormonal IUDs, like the Mirena, come with a 3-6 percent expulsion rate in the first year. Comparatively, the copper IUD is associated with a 3-10 percent risk of expulsion in the first year.

Who is at risk of IUD expulsion?

Women with a history of heavy (menorrhagia) or incredibly painful periods (dysmenorrhea) are at higher risk of expulsion. Postpartum women may also be at higher risk for expulsion.

If you’ve already had IUD expulsion then it is estimated that your risk of another is about fourteen percent.

What are the symptoms of expulsion?

More than the usual cramping, either with your period or outside of menses, can be a sign of expulsion. If you experience a significant increase in bleeding, continuous spotting, new vaginal discharge then you’ll want to see your doctor and possibly have a transvaginal ultrasound to check out where your IUD is currently residing.

Hormonal IUD Side Effects

The progestin contained in the Mirena and other hormonal IUDs contribute to several side effects that can seriously interfere with your life. If you find yourself struggling with any of these then it is a good time to chat with your doc and determine if this is really the best birth control for you.

If you need help transitioning off and getting your hormones back in balance then I invite you to check out my free resource: Post-Birth Control Quick Start Guide.

1. Missing Periods

A missing period occurs in about twenty percent of women with an IUD. It appears that the higher the progestin (remember, Mirena is the highest) then the higher the rate of amenorrhea (aka missing period). In my medical practice I have seen women lose their period within months of having the Mirena replaced and then struggle to get it back when they remove the IUD five years later.

2. Unpredictable or Just Plain Weird Periods

Other women don’t lose their period and instead experience unpredictable, long and intermittent periods.

Studies have shown that as many as fifty nine percent of women experience longer periods. As many as fifty two percent get their period at a random time and about thirty percent spot.

In my clinical practice, I’ve worked with patients who have spotted continuously for months after having their IUD placed. This warrants a trip to the doctor who placed it to make sure everything is ok, but this can be a side effect seen with hormonal IUDs.

And with progestin based contraceptives, you can still ovulate, which makes things even more complicated.

3. Breast Cancer Risk

A study in the New England Journal of Medicine that looked at 1.8 million women ages 15 to 49 years and found that hormonal contraceptives, including IUDs, were associated with an increased risk of breast cancer.

They found a twenty percent increased risk of breast cancer in women who used hormonal birth control compared to women using non-hormonal forms of contraception, like condoms, non-hormonal IUD, or FAM.

In my practice, if a woman has a family history or personal history of breast cancer we look to other options of birth control.

4. Mirena Side Effects Mood

I’ll never forget my first patient years ago who told me she felt “crazy” when her IUD was placed. She was having panic attacks that alternated with depression. Her gynecologist told her the only option was to begin several mood altering drugs. She came to me in hopes of fixing her mood swings for good.

But she already had the answer.

She had tracked her symptoms and it was so clear that her mood swings began with the IUD. We worked for three months together to try to get her relief because she did not want to have it removed.

At month four, she was done.

She had her IUD removed and followed my Post-Birth Control Syndrome Protocol diligently. Within weeks she felt like herself again and all of her mood symptoms were gone. Remember earlier when when we were asking if Mirena messes with your hormones?

When she came back to my clinic she shared that her gynecologist dismissed the IUD had contributed in any way to her mood swings. “I felt unheard and like what I was saying didn’t matter to her at all. In her mind, I was the liar and the IUD was the perfect solution to every woman’s problems,” she shared.

Here’s the deal. These hormones can and do contribute to mood symptoms in women. Ask any woman who has lived through it and you’ll know how true that is. But there are also studies to support it!

There's not just a connection between Mirena and mood swings. Studies have shown young women who use hormonal contraceptives, including the IUD, have three times the risk of suicide compared to women who have never used hormonal birth control. Yikes!

Depression (and anxiety) are commonly reported with hormonal contraceptives, the hormonal IUD being no exception. If you have a history or family history of depression, you may want to consider non-hormonal alternatives.

Looking to support your body on or off hormonal birth control? Grab the Hormonal Birth Control Quick Start Guide

5. Pelvic Inflammatory Disease

It is estimated that about one percent of women who get the Mirena IUD placed will develop a serious infection known as Pelvic Inflammatory Disease (PID).

6. Nausea

All hormonal birth control can cause nausea. And while the Mirena IUD tends to be lower compared to the pill, it is still a side effect you should know about.

7. Ovarian Cysts

There is an increased risk of developing ovarian cysts with the Mirena. This is estimated to occur in about twelve percent of women.

You may not notice you have a cyst and they may go away on their own. Or you may experience sharp pain on one side of your abdomen. If it’s the later, get to your doctor and get it checked out.

8. Headaches and Migraines

Headaches are a common side effect of most hormonal birth control options. If you develop new onset of headaches or migraines it is important to discuss this with your doctor.

9. Bloated Belly and Other Gut Trouble

I’ve seen many patients who complain of bloating after having their IUD placed. We are just at the cusp of understanding how our gut, microbiota and hormones interact, but we do know they are all intimately linked.

In my practice, I’ve reviewed women’s timelines and found that all their digestive symptoms began following the IUD placement. Some of these patients have gone on to be diagnosed with SIBO, yeast overgrowth and bacterial dysbiosis.

While we can not say definitely that the IUD causes digestive issues, it is definitely a symptom I tell my patients to be on the lookout for.

10. Acne, Hair Loss, and Funky Skin Symptoms

Rashes, acne, eczema, growth of hair on your chin and hair loss have all been reported by women who use progestin based contraceptives. If you develop any of these then that is a sure sign that the IUD is not your friend.

How to Balance Hormones While on Mirena

Struggling to kick those synthetic hormones for good? If you're a woman facing difficulty with your hormonal IUD or feeling fearful of Post-Birth Control Syndrome, I want you to know your symptoms are not in your head. Many women experience this condition, in fact, clinically I see that the majority of women struggle to balance their hormones post-IUD. And most women experience some form of Post-Birth Control Syndrome.

The good news is that it can be reversed and you can restore health, hormone balance and maintain your fertility if motherhood is in the plans.

In need of more support? I invite you to check out my Birth Control Hormone Reset.

This is the first and only physician designed program to teach you how to transition off of hormonal birth control, reverse symptoms of PBCS and create amazing hormones!

Within the Birth Control Hormone Reset program you'll be introduced to the Brighten Protocol™. This method was developed within my medical practice and have helped thousands of women who are struggling with PBCS.

birth control depressionDiscover how to get off birth control, kick your unwanted hormone symptoms, and make friends with your period all in 5 weeks!

This program is designed to help women ON hormonal birth control and OFF! If you're not ready to ditch your current contraception then no worries. You can learn what you need to do to take incredible care of your body.

You can learn more about the Post Birth Control Hormone Reset Here!

Get Your FREE Hormone Starter Kit with

7 Day Meal Plan & Recipe Guide

This starter pack is exactly what every woman needs to bring her hormones back into balance!

Hormone Starter



  1. Diedrich JT1, Desai S2, Zhao Q2, Secura G2, Madden T2, Peipert JF2. Association of short-term bleeding and cramping patterns with long-acting reversible contraceptive method satisfaction. Am J Obstet Gynecol. 2015. 212(1). 50.e1-8.
  2. Eric M. Heinberg, MD, MPH, Travis W. McCoy, MD, and Resad Pasic, MD, PhD. The Perforated Intrauterine Device: Endoscopic Retrieval. JSLS. 2008. 12(1). 97–100.
  3. Hubacher D1, Grimes DA, Gemzell-Danielsson K. Pitfalls of research linking the intrauterine device to pelvic inflammatory disease. Obstet Gynecol. 2013. 121(5). 1091-8.
  4. Heartwell SF, Schlesselman S.. Risk of uterine perforation among users of intrauterine devices. Obstet Gynecol. 1983. 61(1). 31-6.
  5. Heinemann K1, Reed S2, Moehner S2, Minh TD2.. Risk of uterine perforation with levonorgestrel-releasing and copper intrauterine devices in the European Active Surveillance Study on Intrauterine Devices. Contraception. 2015. 91(4). 274-9.
  6. Sivin I1, Stern J. Health during prolonged use of levonorgestrel 20 micrograms/d and the copper TCu 380Ag intrauterine contraceptive devices: a multicenter study. International Committee for Contraception Research (ICCR). Fertil Steril. 1994. 61(1). 70-7.
  7. De la Cruz D1, Cruz A, Arteaga M, Castillo L, Tovalin H. Blood copper levels in Mexican users of the T380A IUD. Contraception. 2005. 72(2). 122-5.
  8. ParaGard Packet Insert.
  9. Mirena Packet Insert.
  10. Kyleena Packet Insert.
  11. Sklya Packet Insert.
About The Author

Dr. Jolene Brighten

Facebook Twitter

Dr. Jolene Brighten, NMD, is a women’s hormone expert and prominent leader in women’s medicine. As a licensed naturopathic physician who is board certified in naturopathic endocrinology, she takes an integrative approach in her clinical practice. A fierce patient advocate and completely dedicated to uncovering the root cause of hormonal imbalances, Dr. Brighten empowers women worldwide to take control of their health and their hormones. She is the best selling author of Beyond the Pill and Healing Your Body Naturally After Childbirth. Dr. Brighten is an international speaker, clinical educator, medical advisor within the tech community, and considered a leading authority on women’s health. She is a member of the MindBodyGreen Collective and a faculty member for the American Academy of Anti Aging Medicine. Her work has been featured in the New York Post, Forbes, Cosmopolitan, Huffington Post, Bustle, The Guardian, Sports Illustrated, Elle, and ABC News. Read more about me here.